Mary E. Burke (c. 1844-?) was born in Greencastle, Pennsylvania, and died in an unknown location. Burke, along with her sister, Hellen J. Durfee, and her sister's husband, George H. Durfee, studied with Mary Baker Eddy in early 1882, when Eddy and her husband, Asa Gilbert Eddy, visited Washington, D.C. There is no record of Burke joining the Christian Scientist Association or the Church of Christ (Scientist).

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